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I have been using Macrobid for a couple of years now. I am allergic to all other medications and therefore this is all I have to work with. It works well, doesn't always work for me. Sometimes I have to take a second week of it. I often feel the same way as others. Headache if I haven't drank enough water, upset stomach if I hadn't ate enough food when taking the pill. It does make me tired as well. I try to eat well when I am on this medication to help with the energy level since I am allergic to caffeine and can't take that path. I think that if you make sure to take the pill with lots of food like they recommend, the nausea isn't that bad. Also, drinking more water then your ever use to, will help with the headaches.