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I started using Protopic on Dec. 1st and alternating it with Desoximetasone per my doctors orders. At first the dermatitis cleared up on my hands (that would crack and bleed and then the skin would get hard and peel off and once it peeled off the new skin was very tender and there was a lot of pain. Once I started using Protopic--the condition seemed to clear up 90% but never 100%--well here it is Feb 28th and I have spent the entire week since Sunday in bed. I have every side effect listed--my hands itch like crazy, have headache (worst I have ever had) my flu like symptoms are the chills, runny nose (have gone through 2 boxes of Kleenex, sore throat. Hurts to swallow, muscle pains. Absolutely no energy/unusual tiredness.