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I have had frequently reoccurring urinary tract infections for almost 15 years and tried pretty much every trick out there to prevent them, to no avail. When discussing this with an Ob/Gyn she decided to prescribe Macrobid to be taken on days of intercourse in order to prevent me from getting another infection. I went from getting an infection every couple of months to not having one for a year and a half, until I ran out of the medication. The only side effect was a change in urine color which did not have an effect on my quality of life beyond wearing panty liners as a precautionary measure on days I had taken it to ensure my underwear did not get stained. Taking this to prevent infections was a life changer for me.