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I have been on Meridia for almost a week now. I have not weighed myself due to the fact I hate the scale. The drug took effect after about 2 days where I can honestly say that my cravings/snack sessions have ceased, I have begun to try portion control, and it seems to work (where I am satisfied with a lot less). I am not constipated and I do feel like I have more energy, but I'm still able to get a decent nights sleep. I notice if I exercise (even if I don't feel like it) I get energy. My blood pressure is fine thus far, but I will continue to monitor it as I progress. No headaches, or break through bleeding, no stomach aches. I have a slight lower back ache, but that may be to the sit ups being done improperly.