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I have had moderate and sometimes severe plaque and guttate psoriasis for 16 years, using clobetasol (clobex) for 14. Clobex is the only thing that can eliminate my psoriasis almost completely. It is a very effective drug, but I feel I really should warn people of the devastating effects that can occur if the drug is applied continuously. When using clobex or any other strong topical corticosteroid, you are supposed to use it for no more than 2 weeks, then take a break I believe should be between 2 and 3 weeks. I made the mistake of not doing that. I used it continuously because I wanted to be clear. Now, my skin is paper thin. Nearly every vein is visible, and I break blood vessels constantly, and I have stretch marks everywhere.