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My doctor explained me that Estradiol Valerate is an estrogen hormone that helps women solve some problems with their health. It works by replacing natural estrogens in women after the menopause. Personally I have found that using this medication it takes my postmenopausal symptoms away almost immediately. It is wonderful and has controlled my hotflashes, night sweats, breast tenderness, and dry skin. Within a week of starting the drug, all of these symptoms were resolved. To date, I've not experienced any side effects.