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I am taking progesterone suppositories to help sustain my pregnancy after a miscarriage due to insufficient progesterone levels. I began taking it at 4 wks pregnant, and am now 9 weeks along. My side effects have included drowsiness, cramping, bloating and upset stomach. A rather unfortunate side effects has also been vaginal itching and dryness that leads to major discomfort for the hour or two after I have inserted the medication. These are little issues that feel big, but in the grand scheme of things, if this medication helps me to have a healthy pregnany and baby, it will be well worth it.