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I have been a migraine sufferer for over 30 years, and several of the "triptans" have proved to be effective as I've found out as my insurance has dictated, but Zomig continues to be my go to remedy. Over 10 years ago I found that if I took a triptan and lit a cigarette, my heart would race. That was probably a very good thing, as the choice between getting rid of the migraines or getting rid of the cigarettes became easy. Zomig allows me to function even when I wake up with a full blown migraine. I count on it!