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I have a genetic condition called Venous Insufficiency, which doesn't allow the blood & fluid to be returned from my lower legs & feet, so they swell and the skin can start to break down, which opens up the opportunity for infection. Have been taking Furosemide 40mg 1x day for over a year now - it is the only thing that keeps me from being in the hospital all the time with infections that require IV antibiotics. The only side effects I've noticed are the very frequent urination (not really a side effect, it's what the drug is *supposed* to do, as it flushes fluids out of the body), and aching in my legs and feet as the fluid leaves - I can only assume that is caused by my body trying to push the fluid out.