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After years struggling with acute Eczema, I was prescribed UVB 3 times a week. It worked for a while, then the effectiveness wore off slowly. Years later, after trying several medicines/creams I was prescribed Neoral 300mg/day. Within days I saw a remarkable recovery, within weeks I was mostly cured. The side effects I suffer from are minute compared to the suffering I have endured previously with Eczema. Most days my hands/feet are burning, so hot they feel cold, extreme temperatures, hot/cold seem to make it worse, when I wash my hands, I can't tell whether the water is ice cold or burning hot. Colds, flu, chest, ear and throat infections make up most of my winters but I still would prefer to take Neoral, than have debilating eczema.