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I decided to start taking sibutramine to lose weight that I had gained last year. I chose this because you can use it long-term, unlike the stimulants. When I first started it I barely noticed any effects (15mg). My weight was 240lbs starting. Then, about a week in I started to notice a major reduction in appetite and was doing quite well. I was able to get down to 231lbs in 1.5 weeks. Sadly this weight loss came with major dysphoric side-effects, such as tremors, anxiety, muscle twitch, insomnia, mood swings, akathesia, etc. It felt like I was poisoned/going crazy. Therefore, I had to stop it. I wish I could have continued as the weight loss was going great. Bad reactions stopped after discontinuing the sibutramine.